Antibodies Beyond HLA

Anti-hla Antibodies Detection Techniques

Kidney transplantation is now accepted to be the best treatment for patients with end-stage renal disease, conferring an increased survival and a better quality of life compared to dialysis [1-2]. There has been an improvement in allograft survival in the last decades [3-4] and mostly in the short-term outcomes, in part because we have a better understanding and a better control of the cellular...

Journal Watch Non-HLA antibodies

The clinical impact of non-HLA specific antibodies either alone or in concert with donor HLA specific antibodies (DSA) has been an intense area of research in kidney transplantation and more recently in thoracic transplantation as well. These non-HLA antigens include receptors expressed by the vascular endothelium such as the G protein coupled receptors (GPCRs), Major Histocompatibility Complex...

Antibodies: beyond Neutralization Plus

Antipeptide antibodies: do they distinguish HLA-alloantigens?

Three immune sera, raised in rabbits against synthetic peptides corresponding in sequence to predetermined regions of the HLA-DQ histocompatibility antigens, were tested for their ability to recognize phenotypically distinct human lymphoblastoid cell lines. The immune sera readily recognize the immunogen. When tested on the cells, they react poorly but seem to exhibit a certain degree of specif...

Anti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion

Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...